[The mechanisms of the antiviral action of the bora-adamantane derivative preparation BG-12].
Identifieur interne : 002D77 ( Main/Exploration ); précédent : 002D76; suivant : 002D78[The mechanisms of the antiviral action of the bora-adamantane derivative preparation BG-12].
Auteurs : S G Markushin ; B V Sinitsyn ; V P Ginzburg ; A M Kha Der ; A I KlimovSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Adamantane (analogues et dérivés), Adamantane (pharmacologie), Antiviraux (antagonistes et inhibiteurs), Antiviraux (pharmacologie), Données de séquences moléculaires, Dépression chimique, Génome viral, Mutation, Protéines virales (), Protéines virales (analyse), Relation dose-effet des médicaments, Réplication virale (), Résistance microbienne aux médicaments (génétique), Séquence nucléotidique, Virus de la grippe A (), Virus de la grippe A (génétique), Virus de la grippe A (physiologie), Virus influenza B (), Virus influenza B (génétique), Virus influenza B (physiologie), Virus recombinants (), Virus recombinants (génétique), Électrophorèse sur gel de polyacrylamide.
- MESH :
- analogues et dérivés : Adamantane.
- analyse : Protéines virales.
- antagonistes et inhibiteurs : Antiviraux.
- génétique : Résistance microbienne aux médicaments, Virus de la grippe A, Virus influenza B, Virus recombinants.
- pharmacologie : Adamantane, Antiviraux.
- physiologie : Virus de la grippe A, Virus influenza B.
- Données de séquences moléculaires, Dépression chimique, Génome viral, Mutation, Protéines virales, Relation dose-effet des médicaments, Réplication virale, Séquence nucléotidique, Virus de la grippe A, Virus influenza B, Virus recombinants, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Adamantane (analogs & derivatives), Adamantane (pharmacology), Antiviral Agents (antagonists & inhibitors), Antiviral Agents (pharmacology), Base Sequence, Depression, Chemical, Dose-Response Relationship, Drug, Drug Resistance, Microbial (genetics), Electrophoresis, Polyacrylamide Gel, Genome, Viral, Influenza A virus (drug effects), Influenza A virus (genetics), Influenza A virus (physiology), Influenza B virus (drug effects), Influenza B virus (genetics), Influenza B virus (physiology), Molecular Sequence Data, Mutation, Reassortant Viruses (drug effects), Reassortant Viruses (genetics), Viral Proteins (analysis), Viral Proteins (drug effects), Virus Replication (drug effects).
- MESH :
- chemical , analogs & derivatives : Adamantane.
- chemical , analysis : Viral Proteins.
- chemical , antagonists & inhibitors : Antiviral Agents.
- chemical , drug effects : Viral Proteins.
- chemical , pharmacology : Adamantane, Antiviral Agents.
- drug effects : Influenza A virus, Influenza B virus, Reassortant Viruses, Virus Replication.
- genetics : Drug Resistance, Microbial, Influenza A virus, Influenza B virus, Reassortant Viruses.
- physiology : Influenza A virus, Influenza B virus.
- Base Sequence, Depression, Chemical, Dose-Response Relationship, Drug, Electrophoresis, Polyacrylamide Gel, Genome, Viral, Molecular Sequence Data, Mutation.
Abstract
The effect of one of the derivatives of boraadamantane, preparation BG-12, on reproduction of influenza type A and B viruses was studied. This preparation was shown to inhibit multiplication of a wide range of influenza type A and B virus strains. It is important that BG-12 inhibits in cell culture the replication of a mutant of fowl plague virus A/FPV/Weibridge resistant to remantadine. BG-12 was found to exert a marked viricidal effect, to inhibit the hemolytic activity of both influenza A and influenza B viruses, but not the neuraminidase activity of these viruses. The synthesis of some virus-specific proteins was found to be disturbed in influenza B/Ann Arbor/86-infected cells in the presence of BG-12. A FPVBAR mutant of influenza A/FPV/Weibridge (H7N7) virus resistant to BG-12 was obtained. All the BG-12-resistant reassortants inherited genes 4 and 7 coding for hemagglutinin (HA) and membrane proteins (M) from FPVBAR mutant, respectively, and the remaining genes from BG-12-sensitive A/Krasnodar/101/59 (H2N2) virus. The sequencing of a region of the M gene encoding for the transmembrane protein M2 revealed the substitution of Ala30-Thre in this protein. Multiple attempts at generating a mutant of influenza type B virus resistant to BG-12 failed.
PubMed: 8073750
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000425
- to stream PubMed, to step Curation: 000425
- to stream PubMed, to step Checkpoint: 000620
- to stream Ncbi, to step Merge: 001306
- to stream Ncbi, to step Curation: 001306
- to stream Ncbi, to step Checkpoint: 001306
- to stream Main, to step Merge: 002F52
- to stream Main, to step Curation: 002D77
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[The mechanisms of the antiviral action of the bora-adamantane derivative preparation BG-12].</title><author><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name></author><author><name sortKey="Sinitsyn, B V" sort="Sinitsyn, B V" uniqKey="Sinitsyn B" first="B V" last="Sinitsyn">B V Sinitsyn</name></author><author><name sortKey="Ginzburg, V P" sort="Ginzburg, V P" uniqKey="Ginzburg V" first="V P" last="Ginzburg">V P Ginzburg</name></author><author><name sortKey="Kha Der, A M" sort="Kha Der, A M" uniqKey="Kha Der A" first="A M" last="Kha Der">A M Kha Der</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1993 May-Jun</MedlineDate></PubDate></date><idno type="RBID">pubmed:8073750</idno><idno type="pmid">8073750</idno><idno type="wicri:Area/PubMed/Corpus">000425</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000425</idno><idno type="wicri:Area/PubMed/Curation">000425</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000425</idno><idno type="wicri:Area/PubMed/Checkpoint">000620</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000620</idno><idno type="wicri:Area/Ncbi/Merge">001306</idno><idno type="wicri:Area/Ncbi/Curation">001306</idno><idno type="wicri:Area/Ncbi/Checkpoint">001306</idno><idno type="wicri:doubleKey">0507-4088::Markushin S:the:mechanisms:of</idno><idno type="wicri:Area/Main/Merge">002F52</idno><idno type="wicri:Area/Main/Curation">002D77</idno><idno type="wicri:Area/Main/Exploration">002D77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[The mechanisms of the antiviral action of the bora-adamantane derivative preparation BG-12].</title><author><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name></author><author><name sortKey="Sinitsyn, B V" sort="Sinitsyn, B V" uniqKey="Sinitsyn B" first="B V" last="Sinitsyn">B V Sinitsyn</name></author><author><name sortKey="Ginzburg, V P" sort="Ginzburg, V P" uniqKey="Ginzburg V" first="V P" last="Ginzburg">V P Ginzburg</name></author><author><name sortKey="Kha Der, A M" sort="Kha Der, A M" uniqKey="Kha Der A" first="A M" last="Kha Der">A M Kha Der</name></author><author><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adamantane (analogs & derivatives)</term><term>Adamantane (pharmacology)</term><term>Antiviral Agents (antagonists & inhibitors)</term><term>Antiviral Agents (pharmacology)</term><term>Base Sequence</term><term>Depression, Chemical</term><term>Dose-Response Relationship, Drug</term><term>Drug Resistance, Microbial (genetics)</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Genome, Viral</term><term>Influenza A virus (drug effects)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (physiology)</term><term>Influenza B virus (drug effects)</term><term>Influenza B virus (genetics)</term><term>Influenza B virus (physiology)</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Reassortant Viruses (drug effects)</term><term>Reassortant Viruses (genetics)</term><term>Viral Proteins (analysis)</term><term>Viral Proteins (drug effects)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adamantane (analogues et dérivés)</term><term>Adamantane (pharmacologie)</term><term>Antiviraux (antagonistes et inhibiteurs)</term><term>Antiviraux (pharmacologie)</term><term>Données de séquences moléculaires</term><term>Dépression chimique</term><term>Génome viral</term><term>Mutation</term><term>Protéines virales ()</term><term>Protéines virales (analyse)</term><term>Relation dose-effet des médicaments</term><term>Réplication virale ()</term><term>Résistance microbienne aux médicaments (génétique)</term><term>Séquence nucléotidique</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (physiologie)</term><term>Virus influenza B ()</term><term>Virus influenza B (génétique)</term><term>Virus influenza B (physiologie)</term><term>Virus recombinants ()</term><term>Virus recombinants (génétique)</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Adamantane</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adamantane</term><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adamantane</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term><term>Reassortant Viruses</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Microbial</term><term>Influenza A virus</term><term>Influenza B virus</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Résistance microbienne aux médicaments</term><term>Virus de la grippe A</term><term>Virus influenza B</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Adamantane</term><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term><term>Virus influenza B</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term><term>Influenza B virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term><term>Depression, Chemical</term><term>Dose-Response Relationship, Drug</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Genome, Viral</term><term>Molecular Sequence Data</term><term>Mutation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Données de séquences moléculaires</term><term>Dépression chimique</term><term>Génome viral</term><term>Mutation</term><term>Protéines virales</term><term>Relation dose-effet des médicaments</term><term>Réplication virale</term><term>Séquence nucléotidique</term><term>Virus de la grippe A</term><term>Virus influenza B</term><term>Virus recombinants</term><term>Électrophorèse sur gel de polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of one of the derivatives of boraadamantane, preparation BG-12, on reproduction of influenza type A and B viruses was studied. This preparation was shown to inhibit multiplication of a wide range of influenza type A and B virus strains. It is important that BG-12 inhibits in cell culture the replication of a mutant of fowl plague virus A/FPV/Weibridge resistant to remantadine. BG-12 was found to exert a marked viricidal effect, to inhibit the hemolytic activity of both influenza A and influenza B viruses, but not the neuraminidase activity of these viruses. The synthesis of some virus-specific proteins was found to be disturbed in influenza B/Ann Arbor/86-infected cells in the presence of BG-12. A FPVBAR mutant of influenza A/FPV/Weibridge (H7N7) virus resistant to BG-12 was obtained. All the BG-12-resistant reassortants inherited genes 4 and 7 coding for hemagglutinin (HA) and membrane proteins (M) from FPVBAR mutant, respectively, and the remaining genes from BG-12-sensitive A/Krasnodar/101/59 (H2N2) virus. The sequencing of a region of the M gene encoding for the transmembrane protein M2 revealed the substitution of Ala30-Thre in this protein. Multiple attempts at generating a mutant of influenza type B virus resistant to BG-12 failed.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ginzburg, V P" sort="Ginzburg, V P" uniqKey="Ginzburg V" first="V P" last="Ginzburg">V P Ginzburg</name><name sortKey="Kha Der, A M" sort="Kha Der, A M" uniqKey="Kha Der A" first="A M" last="Kha Der">A M Kha Der</name><name sortKey="Klimov, A I" sort="Klimov, A I" uniqKey="Klimov A" first="A I" last="Klimov">A I Klimov</name><name sortKey="Markushin, S G" sort="Markushin, S G" uniqKey="Markushin S" first="S G" last="Markushin">S G Markushin</name><name sortKey="Sinitsyn, B V" sort="Sinitsyn, B V" uniqKey="Sinitsyn B" first="B V" last="Sinitsyn">B V Sinitsyn</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D77 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D77 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:8073750
|texte= [The mechanisms of the antiviral action of the bora-adamantane derivative preparation BG-12].
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8073750" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |